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Celexa Information

Citalopram, marketed as Celexa, is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat major depression and is often prescribed off-label to treat a wide variety of conditions. Originally created in 1989 by the pharmaceutical company Lundbeck, Celexa is an SSRI antidepressant that is occasionally used to treat attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), and premenstrual dysphoric disorder (PMDD).

Today, Forest Laboratories manufactures and markets Celexa, along with a very similar and a more potent SSRI antidepressant called Lexapro. Celexa (citalopram) and Lexapro (escitalopram) share a very similar pharmacological make-up.


Irving Kirsh told 60 Minutes that the difference between the perceived benefit of a placebo compared with that of an antidepressant is minimal for most.


How are Celexa and Lexapro similar? Imagine the molecular configuration below printed off on a piece of paper pressed against a mirror—Celexa is made of both the paper and the mirror image, and Lexapro is just the mirror image.  Or imagine two hands pressed together—Celexa is both hands and Lexapro is just the left hand. 

When a drug is placed in category C, it means that the drug has not been studied in pregnant women, but has shown harmful side effects on fetuses in animal testing.

Initially, the U.S. Food and Drug Administration (FDA) placed Celexa as a pregnancy “category C” drug. The FDA uses the category system to determine possible risks to a fetus when medicines are taken during pregnancy. When a drug is placed in category C, it means that the drug has not been studied in pregnant women, but has shown harmful side effects on fetuses in animal testing.

In 2005, the FDA released a Public Health Advisory which warned of a possible link between the use of certain SSRI antidepressants (similar to Celexa) during pregnancy and an increased risk of certain cardiovascular defects in newborns. In 2006, the FDA issued a specific warning regarding Celexa. According to the FDA, Celexa, along with other SSRI antidepressants, has been linked to a higher risk of persistent pulmonary hypertension of the newborn (PPHN), a life threatening disorder.

These and other birth defects have been associated with Celexa and Baum Hedlund and Robinson, Calcagnie & Robinson are investigating the possible connection between Celexa and other serious and life threatening congenital defects.